At least 10% of all pediatric cancers are due to inherited cancer predisposition syndromes (~ over 1100 new diagnoses in United States and Canada each year). However, little is taught during training about how to identify, screen, or treat these children and their families. Furthermore, this group of patients faces unique social and psychological pressures related to their high cancer risk. This workshop will provide a primer for the general pediatric oncologist about the emerging clinical field of pediatric cancer genetics. Topics covered will include: common biological principles related to hereditary pediatric cancer syndromes, identification and referral of patients likely to have hereditary cancer predisposition syndromes (based on specific cancers and/or familial patterns of cancers), and the recommended – and sometimes controversial – screening methods for early cancer identification. Finally, participants will hear the perspective of a patient living with Li-Fraumeni Syndrome and the implications of having inherited a cancer predisposition syndrome.